KMID : 1036920180230030148
|
|
Annals of Pediatric Endocrinology & Metabolism 2018 Volume.23 No. 3 p.148 ~ p.153
|
|
Factors affecting height velocity in normal prepubertal children
|
|
Lee Jun-Hui
Kim Seul-Ki Lee Eun-Kyoung Ahn Moon-Bae Kim Shin-Hee Cho Won-Kyoung Cho Kyoung-Soon Jung Min-Ho Suh Byung-Kyu
|
|
Abstract
|
|
|
Purpose: To analyze the effects of clinical and laboratory factors, including insulin-like growth factor (IGF) levels, on the height velocity of normal prepubertal children.
Methods: Ninety-five healthy prepubertal children (33 boys, 62 girls) were enrolled. The mean chronological age was 6.3¡¾1.4 years, with a height standard deviation score (SDS) of -0.88¡¾0.70. IGF-1, IGF binding protein-3 (IGFBP-3), SDS for anthropometric measurements, and changes in SDS for anthropometric measurements were analyzed for 1 year, and their associations with 1-year height velocity were investigated.
Results: The group of children with a 1-year height velocity of ¡Ã6 cm were chronologically younger than the group with a 1-year height velocity of <6 cm (5.9¡¾1.3 years vs. 6.7¡¾1.3 years, P=0.004), with a lesser increase of SDS for body mass index (BMI) over 1 year (-0.18¡¾0.68 vs. 0.13¡¾0.53, P=0.014). There were no differences between the 2 groups in IGF-1 SDS and IGFBP-3 SDS. Multiple linear regression showed that baseline chronological age (r=0.243, P=0.026) and height SDS (r=0.236, P=0.030) were positively associated with IGF-1 SDS. Binomial logistic regression showed that an older chronologic age at referral (odds ratio [OR], 0.68; 95% confidence interval [CI], 0.47?0.99) and an increase of BMI SDS over 1 year (OR, 0.41; 95% CI, 0.18?0.89) were associated with a decreased growth possibility of an above-average height velocity (¡Ã6 cm/yr).
Conclusions: Height velocity of normal prepubertal children is affected by an increase of BMI SDS and chronological age. Prepubertal IGF-1 SDS reflects height SDS at the time of measurement but is not associated with subsequent height velocity.
|
|
KEYWORD
|
|
Height velocity, Body mass index, Insulin-like growth factor, Normal prepubertal children
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|
|